The role of polymorphisms in ADAM33, a disintegrin and metalloprotease 33, in childhood asthma and lung function in two German populations
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چکیده
منابع مشابه
The role of polymorphisms in ADAM33, a disintegrin and metalloprotease 33, in childhood asthma and lung function in two German populations
BACKGROUND ADAM33, the first asthma candidate gene identified by positional cloning, may be associated with childhood asthma, lung function decline and bronchial hyperresponsiveness. However, replication results have been inconclusive in smaller previous study populations probably due to inconsistencies in asthma phenotypes or yet unknown environmental influences. Thus, we tried to further eluc...
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RATIONALE A disintegrin and metalloprotease 33 (ADAM33) has been identified as a susceptibility gene for asthma and single nucleotide polymorphisms (SNPs) in this gene have been associated with excessive decline of lung function in individuals with asthma. OBJECTIVES To assess whether SNPs in ADAM33 are associated with accelerated lung function loss in the general population and with chronic ...
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ژورنال
عنوان ژورنال: Respiratory Research
سال: 2006
ISSN: 1465-993X
DOI: 10.1186/1465-9921-7-91